Effective antiprotease-antibiotic treatment of experimental anthrax
نویسندگان
چکیده
منابع مشابه
Effective antiprotease-antibiotic treatment of experimental anthrax
BACKGROUND Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic lesions, to host tissues and organs. It is widely believed that anthrax lethal toxin secreted by proliferating bacteria is a major cause of death, however, the pathology of intoxication in experimental animals is drastically diff...
متن کاملAntibiotic treatment of anthrax infection in mice.
Quantitative measurements of mean time to death, percentage of survivors, and viable cell populations in the whole body were employed to determine the effects of penicillin, dihydrostreptomycin, chlortetracycline, oxytetracycline, chloramphenicol, and antiserum on the course of anthrax infection in mice. By all parameters tested, penicillin and dihydrostreptomycin were most effective in the tre...
متن کاملA short course of antibiotic treatment is effective in preventing death from experimental inhalational anthrax after discontinuing antibiotics.
BACKGROUND Postexposure prophylaxis of inhalational anthrax requires prolonged antibiotic therapy or antibiotics and vaccination. The duration of treatment for established anthrax is controversial, because retained spores may germinate and cause disease after antibiotics are discontinued. Using rhesus macaques, we determined whether a short course of antibiotic treatment, as opposed to prophyla...
متن کاملTreatment of experimental anthrax with recombinant capsule depolymerase.
Bacillus anthracis produces an antiphagocytic gamma-linked poly-D-glutamic acid capsule that is required for virulence. Capsule depolymerase (CapD) is a membrane-associated poly-gamma-glutamate-specific depolymerase encoded on the B. anthracis capsule plasmid, pX02, that is reported to contribute to virulence by anchoring the capsule to the peptidoglycan and partially degrading high-molecular-w...
متن کاملIs in vitro antibiotic combination more effective than single-drug therapy against anthrax?
Antibiotic combinations are used to enhance antibacterial efficacy and to prevent the development of resistance. We have tested a possible synergistic effect of several antibacterial combinations on Bacillus anthracis. The in vitro activities of antibiotic combinations against two strains of B. anthracis, strain Sterne and the Russian anthrax vaccine strain STi, were tested by the fractional in...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2005
ISSN: 1471-2334
DOI: 10.1186/1471-2334-5-25